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Contents
Common use
Zofran (ondansetron) is a prescription anti-nausea medication primarily used to prevent and relieve vomiting and nausea resulting from chemotherapy, radiation treatments, and surgical procedures.
It works by blocking the action of serotonin (5-HT3 receptors) in the brain and gastrointestinal system - key areas that trigger the vomiting reflex. Zofran is commonly used in both adult and pediatric patients, especially during cancer therapy and anesthesia recovery.
Dosage and direction
Zofran is formulated in oral tablets, orally dissolving tablets (ODT), and injectable forms.
For adults undergoing chemotherapy, a standard dose is 8 mg taken 30 minutes before treatment, followed by 8 mg every 8 to 12 hours for up to two days.
In postoperative settings, a single 4 mg dose is commonly given to prevent or control nausea.
Use this medication exactly as instructed. Do not chew or crush orally disintegrating tablets - allow them to dissolve gently in the mouth.
Precautions
Before taking Zofran, make sure your doctor knows if you have:
• Liver conditions
• A personal or family history of heart rhythm issues (such as prolonged QT interval)
• Abnormal electrolyte levels (low potassium or magnesium)
• Sensitivity to ondansetron or other antiemetics
Zofran may cause lightheadedness or drowsiness, so avoid driving or operating machinery until you know how it affects you.
Contraindications
Do not use Zofran if you:
• Are allergic to ondansetron or similar medications
• Are concurrently using apomorphine
The safety of Zofran in pregnancy is not fully established. Speak with your physician if you are pregnant, breastfeeding, or planning pregnancy.
Possible side effects
Common adverse reactions may include:
• Mild headache
• Tiredness or fatigue
• Constipation
• Dizziness
Serious effects (rare):
• Heart rhythm abnormalities
• Visual disturbances
• Serotonin syndrome (especially when combined with other serotonergic drugs)
Seek urgent medical help if you experience difficulty breathing, rash, facial swelling, or chest discomfort.
Drug interactions
Zofran may interact with the following substances:
• SSRIs and SNRIs (e.g., fluoxetine, sertraline)
• Tramadol
• Medications that affect cardiac rhythm
• Antiseizure drugs
• Apomorphine (should not be used together)
Always disclose all medications, supplements, and herbal products you are using to your healthcare provider.
Missed dose
If you forget a dose and are still experiencing nausea, take it as soon as possible. If your next dose is near, skip the missed one and resume your regular schedule. Avoid taking a double dose.
Overdose
Signs of an overdose may include:
• Temporary vision loss
• Serious constipation
• Irregular heartbeat or arrhythmias
In case of overdose, call poison control or emergency services right away.
Storage
Keep Zofran stored at controlled room temperature (68°-77°;F / 20°-25°;C). Protect from moisture, heat, and direct sunlight. Always store out of reach of children and pets.
U.S. Sale and Prescription Policy
Zofran is an FDA-approved antiemetic medication that typically requires a valid doctor's prescription in the United States. This regulation is in place due to possible heart-related side effects and other health risks.
However, Home Care Pharmacy offers eligible individuals the option to obtain Zofran without a traditional prescription, through a pharmacist-guided consultation process - where legally permitted. This service may allow patients to access medication more conveniently while maintaining proper medical oversight.
Please contact Home Care Pharmacy for details on regional availability and eligibility.
Disclaimer
This material is intended for informational purposes only and does not replace medical advice from licensed professionals. Always consult your doctor or pharmacist before beginning any new treatment. We are not responsible for the misuse, interpretation, or misapplication of the information presented.