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Contents
Common use
Motilium (domperidone) is a dopamine receptor antagonist designed to enhance the movement of food through the upper digestive tract. It is widely used for managing symptoms such as:
Nausea and vomiting
Abdominal bloating
Gastrointestinal discomfort
Gastroparesis (delayed stomach emptying)
Additionally, domperidone is sometimes prescribed off-label to promote lactation in women experiencing difficulties with breast milk production, under medical supervision.
Dosage and direction
Follow your healthcare provider's instructions carefully. The typical adult dosage is 10 mg taken 15 to 30 minutes before meals, up to three times daily. In some cases, it may be prescribed at bedtime as well.
Swallow the tablet whole with a full glass of water. Do not chew, crush, or dissolve the tablet unless directed.
Long-term use and high doses should be avoided unless explicitly approved by your physician.
Precautions
Before taking Motilium, inform your healthcare provider if you have any of the following:
Liver dysfunction
Pre-existing heart rhythm conditions (e.g., QT interval prolongation)
Electrolyte abnormalities (e.g., low potassium or magnesium)
Intestinal blockage or bleeding
Caution is advised for elderly patients and those with a history of cardiac disease. Alcohol consumption should be avoided due to increased risk of drowsiness and adverse effects.
Contraindications
Motilium should not be used if you:
Are allergic to domperidone or any of its ingredients
Have moderate to severe liver problems
Are taking medications that inhibit CYP3A4 enzymes, such as certain antifungals or antibiotics
Have known issues with cardiac conduction or abnormal heart rhythms
Possible side effects
Commonly reported side effects include:
Dry mouth
Stomach cramps
Mild headache
Sleepiness or dizziness
Infrequent but more serious adverse reactions may include:
Abnormal lactation or breast tenderness
Palpitations or irregular heartbeat
Neurological symptoms (e.g., tremors, restlessness)
Severe allergic reactions (rash, itching, facial swelling)
Seek prompt medical help if any unusual symptoms develop.
Drug interactions
Motilium may interact with a number of drugs. Use caution if you are taking:
Antifungals such as ketoconazole or itraconazole
Macrolide antibiotics like erythromycin or clarithromycin
Heart rhythm medications (e.g., amiodarone)
Antidepressants (e.g., sertraline, fluoxetine)
Avoid combining with other dopamine-affecting drugs unless advised by your healthcare provider.
Missed dose
If you forget a dose, take it as soon as you remember. If your next dose is near, skip the missed one and return to your normal schedule. Never take a double dose to make up for a missed one.
Overdose
An overdose of domperidone can lead to serious consequences, including agitation, uncontrolled muscle movements, confusion, or abnormal heart rhythms. Emergency medical attention is required in such cases.
Storage
Keep Motilium in a cool, dry place at room temperature (68°-77°;F / 20°-25°;C). Protect the medication from light, moisture, and heat. Store safely away from the reach of children and pets.
U.S. Sale and Prescription Policy
Motilium (domperidone) is not approved by the U.S. FDA for general consumer use due to concerns over cardiac safety. It is typically available only via investigational protocols for patients with diagnosed gastrointestinal motility disorders.
In most circumstances, purchasing domperidone without a prescription is not permitted within the United States.
However, Home Care Pharmacy offers access to domperidone through legal and compliant channels. In certain jurisdictions where local law allows pharmacist-managed care or direct access programs, it is possible to obtain Motilium without a traditional prescription. Patients are encouraged to consult the pharmacy directly for eligibility and safety assessment.
Disclaimer
This content is for educational purposes only and does not replace the advice of a qualified healthcare professional. Always consult your doctor or pharmacist before using any medication, especially when considering non-standard access options.