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Contents
Common use
Antabuse, also known by its generic name disulfiram, is a medication commonly used as part of long-term therapy for individuals struggling with alcohol dependence. It works by blocking the enzyme involved in alcohol metabolism, causing adverse reactions'such as flushing, nausea, vomiting, and a rapid heartbeat - if alcohol is consumed.
While it does not eliminate alcohol cravings, Antabuse serves as a psychological deterrent and is generally used alongside counseling and support programs to encourage sobriety.
Dosage and direction
This medication is usually taken orally once per day, preferably in the morning. Your healthcare provider may begin treatment at a lower dose (e.g., 250 mg) and adjust based on your needs and tolerance.
You must avoid alcohol for at least 12 hours prior to your first dose. The alcohol-sensitizing effects of Antabuse may persist for up to two weeks after discontinuation.
Take the tablet with or without food and swallow with a full glass of water without crushing or chewing.
Precautions
Inform your healthcare provider before starting Antabuse if you have a history of:
Liver dysfunction
Cardiovascular conditions
Epileptic seizures
Mental health disorders
Diabetes mellitus
Avoid accidental exposure to hidden sources of alcohol, including:
Aftershave, mouthwash, or perfume
Certain vinegars or fermented products
Cold and cough medications containing ethanol
Antabuse may cause drowsiness or reduced alertness, especially in early stages of treatment. Avoid driving or using heavy machinery until you understand its effects on your body.
Contraindications
Do not use Antabuse if you:
Have consumed alcohol in the past 12 hours
Have a history of severe coronary artery disease or psychotic disorders
Are allergic to disulfiram or other thiuram derivatives
Are pregnant or nursing without your doctor's approval
Possible side effects
Frequently reported side effects include:
Sleep disturbances or drowsiness
Metallic or garlic-like taste
Mild skin eruptions or acne
Rare but serious reactions:
Hepatic toxicity (yellowing of skin or eyes)
Peripheral neuropathy (numbness or tingling)
Mood disturbances or psychosis
If you consume alcohol while on Antabuse, symptoms such as difficulty breathing, seizures, and heart irregularities may occur. Seek emergency help in such cases.
Drug interactions
Important interactions may occur if Antabuse is taken with:
Metronidazole (risk of psychotic episodes)
Warfarin (increased risk of bleeding)
Isoniazid, phenytoin, or theophylline
Ensure your healthcare provider is aware of all medications, supplements, and over-the-counter products you use.
Missed dose
If a dose is missed, take it as soon as you remember. If it is near the time for the next scheduled dose, skip the missed dose. Never double up on doses to compensate.
Overdose
Symptoms of overdose may include vomiting, confusion, low blood pressure, seizures, or even unconsciousness. Immediate medical attention is required in such cases.
Storage
Store Antabuse at room temperature (68°-77°;F or 20°-25°;C) in a dry place, protected from excessive heat and moisture. Keep the container tightly sealed and out of the reach of children and pets.
U.S. Sale and Prescription Policy
Antabuse is approved by the FDA and traditionally requires a prescription from a licensed physician in the United States.
However, Home Care Pharmacy offers patients an opportunity to access Antabuse without a prescription where legally allowed, following pharmacist-led screening and professional assessment. This service aims to assist individuals in starting or maintaining sobriety more easily, especially when conventional access is limited.
To ensure quality and authenticity, Antabuse should be obtained only through licensed U.S. pharmacies. Self-medication without appropriate consultation can pose health risks.
Disclaimer
This information is intended for general knowledge only and should not replace professional medical advice or consultation. Always follow the guidance of a qualified healthcare provider regarding diagnosis, treatment, and medication use.